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The reduced DNA repair capacity of APE1 rendered more DNA single strand breaks in RPMI-8226 at 30 min post melphalan treatment when compared to RPMI-8226/LR5.
First they used BE2 system composed of dCas9, therefore will not generate DNA single strand nick.
Consequently, lipid peroxidation, protein oxidation, reduced glutathione (GSH) depletion, and DNA single strand breaks could be initiated by ROS excess.
In the absence of MUC1, these DNA single strands fold into a thermodynamically stable "hairpin" conformation, which facilities direct electron transfer between MB and the gold electrode.
When neutralization step occur, extruded DNA (single and double strand breaks) which are migrate towards anode, formed hair pin loop like structure.
The short range of these electrons requires that cytosolic uptake of GNPs occurs to create DNA single- and double-strand breaks (Zheng et al. 2008).
Similar(28)
TDP1 removes covalent 3′DNA adducts in DNA single-strand break repair.
DNA break, including DNA single-stranded break (SSB) and DNA double-stranded break (DSB), is the most serious DNA damage.
Three protective compounds [ectoin, l-ergothioneine (ERT) and mannitol] were tested with the comet assay for their effectiveness to reduce DNA single-strand breaks (SSB).
Poly(ADP-ribose polymerase 1 (PADP-ribose polymeraseyotic stress sensor that responds in seconds to DNA single-strand breaks (SSBs), the most frequent genomic damage.
In general, DNA damaging agents induce DNA single-strand breaks (SSB) or double-strand breaks (DSB).
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