Your English writing platform
Discover LudwigSuggestions(1)
Similar(60)
DNA methylases appear to have emerged first in bacterial restriction modification (R M) systems from ancient RNA-modifying enzymes, in transitions that involved acquisition of novel catalytic residues and DNA-recognition features.
Even after these initial successes, however, we understand relatively little about the general compound structural features necessary for mixed DNA recognition by most heterocyclic cations.
The binding interactions of two other analogs were evaluated in order to unravel the structural features that contribute to specific DNA recognition.
Molecules synthesized for the purpose of transfection usually include some or all of the following molecular recognition features: cationic groups for electrostatic DNA binding, a hydrophobic part to facilitate transmembrane transfer, and specific recognition entities.
These features may account for the unique DNA recognition and quinolone targeting properties of pneumococcal type II topoisomerases compared to their gram-negative counterparts.
20 Furthermore the specific DNA binding sites of a protein will typically carry recognition features in their structural properties which can be accessed by the protein through 'indirect' readout.
These features make Cas-OFFinder applicable to ZFNs, TALENs and transcription factors that are prone to off-target DNA recognition.
Interestingly, Sox2-mediated DNA recognition is sequence-dependent.
Nevertheless, the new structures reveal some local variations in DNA recognition compared to that seen in the DNA-bound PthXo1.
There were also unique recognition features for each serotype, suggesting that 4E11 has flexible recognition requirements.
Sry contains a distinctive high-mobility group (HMG) domain, which permits precise DNA recognition and binding.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com