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Moreover, the cellular response to Top2 inhibitors is complex and a broad range of DNA processes are implicated.
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The chromatin that controls DNA processes is an epigenetic mechanism in either an active or repressive state.
DNA repair processes are initiated, followed by re-initiation of DNA replication (one of the eleven GO categories enriched in cluster 1).
DNA repair processes are responsible for maintaining genome stability.
Therefore, we estimate that the main products in DNA damage processes are DSBCs which phosphorylate ATM.
DNA-repair processes are constantly active as they respond to permanently occurring damages in the DNA structure.
In eukaryotes, all DNA-templated processes are tightly connected to chromatin structure and function.
These DNA-bound processes are chiefly replication and transcription.
For therapeutic purposes DNA damage signalling processes are induced to induce apoptosis in tumour cells.
At 30 minutes, no term was significantly up-regulated, only "DNA metabolic processes" was down-regulated in the leaf.
The efficiency of plus-strand template switch steps and and DNA elongation processes were always decreased when serines were replaced with alanines (Fig. 4).
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