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DNA patterns were analyzed visually and by using Diversity software (Bio-Rad).
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Sequences from at least 12 individual clones per locus and genotype were obtained and DNA methylation patterns were analyzed using CyMATE software.
Genome-wide DNA methylation patterns were analyzed using the Illumina 450K Human Methylation Array, which interrogates over 480,000 CpG dinucleotides in the genome, including over 4000 on Chromosome 21 itself, and were correlated with scores related to cognitive function.
DNA banding patterns were analyzed using bioNumerics software (Applied Maths) to calculate Dice coefficients of correlation and to generate a dendrogram using the unweighted pair group method of arithmetic averages (UPGMA) clustering.
Using a technology that can potentially be easily transferred into a clinical laboratory (digestion with a methylation-sensitive restriction enzyme followed by multiplexed real-time PCR amplification), a panel of 63 multiplex PCR assays was devised and the DNA methylation patterns were analyzed in 204 sera/plasma yielding a high AUC of 0.91 for lung cancer and slightly less for ILD and COPD.
The O6-methylguanine-DNA methyl transferase (MGMT) promoter methylation patterns were analyzed as previously described.
Banding patterns were analyzed visually.
All patterns were analyzed individually.
Expression patterns were analyzed by Western blotting.
Bacterial findings and resistance patterns were analyzed.
The ring patterns are analyzed.
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