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In addition to normal DNA methylation, variations and derivatives of the methyl mark on CpG dinucleotides have also been reported, including hydroxymethyl, formyl, and carboxyl groups, as well as methyl marks that occur at non‐CpG sites.
Previous studies on DNA methylation in embryo and endosperm using DNA methylation microarray, immunoprecipitation and MSAP have assessed only a small portion of tissue-specific DNA methylation variations in maize genome [ 29, 31, 35, 37, 45, 46].
Pathways analysis of significant DNA methylation variations and network analysis performed using Ingenuity Pathway Analysis (IPA).
Guay SP, Brisson D, Lamarche B, Marceau P, Vohl MC, Gaudet D, et al. DNA methylation variations at CETP and LPL gene promoter loci: New molecular biomarkers associated with blood lipid profile variability.
Byun HM, Nordio F, Coull B, Tarantini L, Hou L, Bonzini M et al. Temporal stability of epigenetic markers: sequence characteristics and predictors of short-term DNA methylation variations.
Xu et al reported the overall methylation differences between different tissues and strains of chicken [30], which provided the first attempt to elucidate the DNA methylation variations between chicken breeds with heterogeneous genetic background.
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Similarly, sites of DNA independent DNA methylation variation have been shown to be affected by rearrangements in neighboring regions (Foerster et al. 2011).
Schultz, M.D. et al. Human body epigenome maps reveal noncanonical DNA methylation variation.
Eichten, S. R. et al. Epigenetic and genetic influences on DNA methylation variation in maize populations.
The dataset presented here will allow further analysis and understanding of the mechanisms of sources of DNA methylation variation in healthy individuals and also investigate the relationship between genetic and epigenetic variation.
(b) Overview of the steps and approaches used to generate summaries of abundance of transcripts in healthy neutrophils and identify the relationship of exon usage and DNA methylation variation in our primary research paper.
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