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This suggests that simple and effective gene therapy method using antibody producing minicircle DNA may represent a powerful tool for the transplantation.
The increased preference of BRCA1 for the 2 bp bulged and C∶C mismatch DNA substrates compared to linear duplex and G∶T DNA may represent a mechanism by which these lesions are sensed and repair proteins targeted to ensure the fidelity of HRR.
In addition, our findings potentially suggest that fibrinogen and EBV DNA may represent different signalling pathways or biological behaviours that contribute to NPC progression.
Whereas proviral DNA may represent a record of HLA-imposed selection pressure it may not represent the circulating virus, and therefore associations with viral load etc. may be misleading.
Alternatively, methylation of viral DNA may represent a potential host defense mechanism, with the host aiming to alter viral gene expression once the virus has integrated into the host genome.
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Therefore, non-coding RNA-induced transition of DNA double helix to a triple-stranded conformation with exposed single-stranded DNA sequences may represent a default regulatory state of protein-less DNA interacting with invading RNA molecules within the open chromatin architecture (Lee J, Hwang M, Landon PB, Lal R, Glinsky GV, in preparation).
The link between the crossover geometry and the sign of DNA supercoiling may represent the key to understanding these questions.
Their results suggest that changes in DNA methylation may represent an epigenetic biomarker of dietary AFB1 exposure.
These stimulatory effects are due to unmethylated CpG motifs within the bacterial DNA and may represent a continuous and persistent inflammatory loop [ 30].
The association between lead exposure and LINE-1 DNA methylation may have implications for the mechanisms of action of lead on health outcomes, and also suggests that changes in DNA methylation may represent a biomarker of past lead exposure.
This decline in DNA yield may represent the known decline in total leukocyte and lymphocyte count that occurs between birth and adulthood and is not an explanation for a decrease in buccal cell DNA yield.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com