Lin, J. R., Qin, H. H., Wu, W. Y., He, S. J. & Xu, J. H. Vitamin C protects against UV irradiation-induced apoptosis through reactivating silenced tumor suppressor genes p21 and p16 in a Tet-dependent DNA demethylation manner in human skin cancer cells.
Taken together, these results indicate that while 21OH-6,19OP affects GR's ability to physically interact with TIF2, the other ligands allow this interaction mainly in a DNA dependent manner.
MeCP2 was bound to its target genes in a DNA methylation dependent manner.
Taken together, these data demonstrate that MeCP2 is bound to its target genes in a DNA methylation dependent manner and is lost from these target genes after TAC.
Many in vitro DNA-PKcs autophosphorylation sites, including Ser, Thr, Thr, Thr and Thr are phosphorylated in a DNA-PK-dependent manner after DNA damage indicating that DNA-PKcs undergoes autophosphorylation in vivo [ 10– 10].
Moreover, they can also act by interfering with transcriptional complex formation in a DNA-independent manner.
Oct-1 was proposed as an AR collaborator [3] and was shown to physically interact with the AR in a DNA-dependent manner that facilitated cofactor recruitment [48], [49].
More recently, several studies suggested that PARP1 activity is also regulated in a DNA-independent manner.
This identity is maintained during cell replication in a heritable but DNA-independent manner.
More recently, we found that c-Myb activates, in a DNA-binding manner, the expression of Slug and it promotes, via Slug, the homing of K562 cells to the bone marrow.
