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Since continual loss of telomeric DNA is predicted to eventually limit cell proliferation, activation of telomerase in cancer cells may represent an important step in the acquisition of the cell immortalization which occurs during tumor progression.
Although the M. prima genome encodes more proteins, it is also less gene-dense than other Thermotogales: only 84.6% of its DNA is predicted to be located within protein-coding regions, in contrast to 88 97% in other Thermotogales genomes.
Since continual loss of telomeric DNA is predicted to eventually limit cell proliferation, activation of telomerase in cancer cells may be an important step in the acquisition of cell immortalisation, which occurs during tumour progression (Counter et al, 1998; Meyerson, 2000).
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The theoretical digestion pattern of DraIII to λ DNA was predicted using NEBcutter (Vincze et al., 2003) and was shown on the left.
Many enzymes potentially involved in the replication of viral DNA are predicted (Table 3, and EU304328).
Putative genes in the genomic DNA were predicted by means of the software FGENESH [ 91].
Because the haploid human genome consists of three billion DNA bp, proteins such as Zif268, which bind nine bp of DNA, are predicted to recognize ∼12 000 distinct sites, making single site recognition virtually impossible.
The increase in nucleosomal DNA length is predicted to stabilize the association of DNA with histones and therefore to prevent nucleosomes from unwrapping.
Although this DNA modification is predicted to affect epigenetic regulation, its specific effects and target genes remain unclear.
This interpretation considers the molecular genetic evidence (such as the effect a DNA change is predicted to have on its corresponding protein product) as it relates directly to the primary clinical concern(s) noted by the ordering physician.
(B ) How these missense mutations affect RUNX1 DNA-binding is predicted based on a previous structural and biochemical analysis of the RUNT domain (Li et al., 2003 ).
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