Sentence examples for dna interactions to from inspiring English sources

Some mobility of the WH domain may be required to allow for flexibility in DNA interactions to accommodate different promoters.

In a previous study, Lieberman-Aiden et al. employed principal component analysis (PCA) on the correlation matrix of DNA interactions to segregate the human genome into two compartments [ 16].

Markov Cluster algorithm (MCL) was then applied to intra-chromosomal DNA interactions to group the genomic bins into clusters such that DNA interaction counts within clusters were greater than those across clusters [ 23].

Instead of the classical one-step model of gene activation, AR also appears to regulate gene expression through a three-step pathway including miR activation, corepressor suppression and DNA interaction to elicit its action.

In view of the significance of these protein-DNA interactions to cellular physiology, we modified the existing InterMine Interaction class, which describes gene-gene interactions, to define a new class named ProteinDNAInteraction.

Additionally, several data types available in TargetMine such as Protein-DNA interactions, to the best of our knowledge, are not made available by other publicly available resources, some of which, including GeneDistiller [52] and PolySearch [53], can perform tasks similar to TargetMine's.

With ChIP-Seq it is common to map the protein-DNA interactions to regions as small as about 300 bp.

This data was combined with known protein-protein and protein-DNA interactions to explore the biological response to deletions in the presence (the G in the column names) or absence of galactose in the medium.

These studies were designed to explore mechanisms of drug-DNA interactions, to make correlations with clinical outcome, and possibly to validate DNA adduct measurements for use in occupational and environmental biomonitoring.

In an attempt to engineer the binding specificity of the lactose operon repressor LacI, Zhan and co-workers [ 29] used the extensive structural and functional knowledge of LacI protein-DNA interactions to design new repressor/operator pairs.

Recently, researchers also have integrated protein-protein and protein-DNA interactions to infer signaling-regulatory pathways, but they focused only on the pathways that explain gene expression changes in response to the knockout genes [ 13].