Sentence examples for dna interactions that from inspiring English sources

At each step along this coordinate, the enzyme must form DNA interactions that are highly specialized for either rapid damage searching or catalysis.

Data presented here providing a good basis for modeling PhoP-promoter DNA interactions that is crucial to the PhoP-mediated transcriptional regulation.

Phosphorylation (or phosphomimetic mutations) of the human RPA2 NT can have an effect in regulating protein interactions and/or DNA interactions that involve the N-terminus of RPA1 (DBD-F).

Hence, protein and DNA interactions that comprise TF networks are fundamental for proper cellular regulation.

In mispaired or ribonucleotide complexes, the fully closed complex is destabilized and, therefore, the partially closed complex remains highly populated (provided that the dNTP concentration is high); this partially closed state is characterized by a high Kd dNTP) (Table 3 and ref (14)) and a DNA interaction that is weaker than in the Pol DNA binary complex [shown by koff values (Table 5)].

Enrichment in regions lacking DRE cores provides additional evidence of AhR-DNA interactions that don not involve the basic bHLH domain [ 63], such as tethering to other DNA interacting TFs and/or tertiary interactions with looping DNA.

We pinpoint specific ComA-DNA interactions that may have a key role for recognition and affinity.

By combining nuclease accessibility, indirect end labeling, and ligation-mediated polymerase chain reaction (PCR) analysis, it is demonstrated that protein-DNA interactions that promote formation of a distal DNase I hypersensitive site do not occur under conditions of hyperacetylation.

Our results suggest that single-molecule approaches can provide insights into the drug-DNA interactions that underlie drug potency and provide information that is complementary to that generated from bulk analysis; thus, single-molecule approaches have the potential to facilitate the selection and design of optimized drug compounds.

These examples emphasise that many protein-DNA interactions that are transient but biologically important would probably escape detection by ChIP.

Clearly, further investigation will be required to determine if the specific protein-DNA interactions that occur in HSV-infected cells are consistent with an ICP0-ICP4 Synergy Model of HSV gene regulation.