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However, if such long-range contacts are dynamic just like the DNA interactions between cis-regulatory elements within a locus [24], [46], they are expected to be disrupted during the time of α-amanitin treatment.
This reinforces the idea that these (erythroid specific) transcription factors, probably in complex with other proteins, are mainly responsible for the stability of the DNA interactions between regulatory elements of the β-globin locus.
In a contrasting model, condensin has been proposed to act by providing DNA interactions between its chromosomal binding sites in a more stochastic manner, without the need to engage into higher order assemblies.
Condensin most likely acts by establishing DNA interactions between its binding sites on DNA strands that happen to come into proximity (D'Ambrosio et al. 2008; Haeusler et al. 2008; Thadani et al. 2012).
Fluoroquinolone antibiotics interfere with DNA interactions between gyrase (GyrAB) or topo IV (ParCE), leading to breaks in DNA, and inducing global repair systems such as the SOS response [ 75, 76].
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We have used fluorescence anisotropy to investigate the DNA interaction between the two human topoisomerase II isoforms, and the impact of the C-terminal domain on this interaction.
Furthermore, we added experimentally confirmed directed protein-DNA interactions between transcription factors and proteins.
Transcription regulatory networks are composed of protein-DNA interactions between transcription factors and their target genes.
So far, we have identified 605 protein-DNA interactions between 115 gene promoters and 176 TFs [ 3, 5- 7].
In total, the database contains 605 protein-DNA interactions between 115 C. elegans gene promoters and 176 TFs.
While mining the full-text literature from 2003, any document that mentioned protein-DNA interactions between any two NR members was also marked (see Additional File 1).
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