Sentence examples for dna interaction that from inspiring English sources

In mispaired or ribonucleotide complexes, the fully closed complex is destabilized and, therefore, the partially closed complex remains highly populated (provided that the dNTP concentration is high); this partially closed state is characterized by a high Kd dNTP) (Table 3 and ref (14)) and a DNA interaction that is weaker than in the Pol DNA binary complex [shown by koff values (Table 5)].

Data presented here providing a good basis for modeling PhoP-promoter DNA interactions that is crucial to the PhoP-mediated transcriptional regulation.

Phosphorylation (or phosphomimetic mutations) of the human RPA2 NT can have an effect in regulating protein interactions and/or DNA interactions that involve the N-terminus of RPA1 (DBD-F).

We are now beginning to understand how genes are switched on and off, regulating the transcriptional activity, however the subtleties of protein-DNA interaction that drive up- or down-regulation remain elusive, especially in what concerns genes under nuclear receptor control.

We report the presence of a DNA interaction motif adjacent to chromodomain in all vertebrate PC homologues and suggest a three-way 'PC-histoneH3-DNA' interaction that can restrict nucleosome dynamics.

Additional aspects of protein-DNA interaction that are analyzed by PDA include "running-into-protein" DNA (when the axis of a double-stranded DNA is blocked by a protein) and "flipped base" (if a base in a double-stranded DNA does not have a base-pairing partner and is in contact with protein).

Hence, protein and DNA interactions that comprise TF networks are fundamental for proper cellular regulation.

Enrichment in regions lacking DRE cores provides additional evidence of AhR-DNA interactions that don not involve the basic bHLH domain [ 63], such as tethering to other DNA interacting TFs and/or tertiary interactions with looping DNA.

We pinpoint specific ComA-DNA interactions that may have a key role for recognition and affinity.

By combining nuclease accessibility, indirect end labeling, and ligation-mediated polymerase chain reaction (PCR) analysis, it is demonstrated that protein-DNA interactions that promote formation of a distal DNase I hypersensitive site do not occur under conditions of hyperacetylation.

Our results suggest that single-molecule approaches can provide insights into the drug-DNA interactions that underlie drug potency and provide information that is complementary to that generated from bulk analysis; thus, single-molecule approaches have the potential to facilitate the selection and design of optimized drug compounds.