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The in vivo protein DNA interaction data are processed using different analysis algorithms (see Methods).
We divided protein telomere DNA interaction data based on whether the particular proteins were known telomere-associated proteins or identified through telomere ChIP studies.
DNA interaction data reported in the present study suggest that the distamycin A backbone drives the brostallicin molecule towards the AT regions present in the minor groove of the DNA.
The DNA interaction data of Escherichia coli, measured by the genome conformation capture (GCC) technique, have recently become available, which allowed us to investigate the spatial features of bacterial genome organization.
The present version of Flynet contains in vivo protein DNA interaction data for 101 datasets for 38 transcription factors (general and sequence specific TFs) and 8 chromatin regulators, including histone modifications in different experimental conditions.
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The 68172 protein-protein and protein-DNA interaction data covering 6814 yeast genes was obtained from Ulitsky and Shamir [8].
We propose here a hidden Markov model (HMM) to incorporate sequence motif information, TF-DNA interaction data and chromatin modification patterns to precisely identify cis-regulatory modules (CRMs).
Thus, results obtained with the IFP-based DNA pull-down assay favorably compare with protein-DNA interaction data obtained using independent experimental setups.
This study offers a bioinformatics strategy to provide testable hypotheses on the mechanisms of microRNA-mediated transcriptional regulation, based upon genome-wide protein-DNA interaction data derived from ChIP-seq experiments.
Much of the work on understanding regulatory networks has focused on Escherichia coli and the yeast Saccharomyces cerevisiae for which protein-protein or protein-DNA interaction data are most abundant.
The purpose of this study is to offer a bioinformatics strategy to provide testable hypotheses on the mechanisms of microRNA-mediated transcriptional regulation, based on genome-wide protein-DNA interaction data derived from ChIP-seq experiments.
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