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Thus, our work establishes the structural basis of AHR assembly and DNA interaction and provides a template for targeted drug design.
The strength of lipids:DNA interaction and the fraction of DNA protected from enzymatic degradation increased with the lipids:DNA ratio.
UV Vis spectroscopic result reveals that the binding mode of interaction of the compound with SS-DNA is intercalative DNA interaction and the intercalative mode of interaction was further supported by viscometry.
Tailored microarrays containing 400.000 probes that each analyze a different DNA interaction and cover 7 complete mouse chromosomes were used [15].
The significantly stronger binding of topoisomerase IIβ once the C terminal domain is removed supports the idea that the C-terminal domain may act as a negative regulator of DNA interaction, and that this could provide a rationale for isoform specific functions in vivo [33].
Finally, DEB and EB differ in their metabolism, mechanism of DNA interaction, and mutagenic potential.
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The chapter also presents an overview of the DNA interactions and other targets for DBQs.
Unconventional DNA-binding proteins (uDBPs) participate in sequence-specific DNA interactions and cellular cytokine responses [33,43].
The basic region facilitates DNA interactions and the HLH domain, protein dimerizations [2], [3].
Asf1 shields H3/H4 dimers from unfavorable DNA interactions and promotes the formation of favorable histone-DNA interactions [ 18].
These methods have translated well to the investigation of protein DNA interactions, yielding insights into the physics of translocases, insights into nonspecific protein DNA interactions, and even complex processes such as transcriptional motion in the presence of nucleosomes.
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