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Not only are these findings useful as a potential biosensing strategy, but also leave an open question about the electronic and synergistic properties of DNA interacting with different materials and surfaces.
Both processes involve trans-regulatory factors (i. e., proteins binding to DNA) interacting, with varying degrees of specificity, with the cis-regulatory elements (i. e., DNA sequences).
SMADs regulate transcription in several ways, including binding to DNA, interacting with other transcription factors, and interacting with transcription corepressors and coactivators like p300 and CBP".
The Smad complex sequence-specifically binds to sites in the DNA, interacting with transcriptional coactivators or corepressors to regulate gene expression.
(6) Similar measurements have been performed on other biological systems including DNA interacting with enzymes such as topoisomerase 308) and the rotational motor F1-ATPase.
Therefore, non-coding RNA-induced transition of DNA double helix to a triple-stranded conformation with exposed single-stranded DNA sequences may represent a default regulatory state of protein-less DNA interacting with invading RNA molecules within the open chromatin architecture (Lee J, Hwang M, Landon PB, Lal R, Glinsky GV, in preparation).
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This suggests that the DNA interacts with mAb C via ionic interaction.
More stable complexes are formed when DNA interacts with HL1 or C60 + HL2 structure.
A single-strand oligonucleotide modified with two digoxin molecules on the two arm segments (capture DNA) interact with hairpin DNA with the help of Ag+ ions.
In these higher-order nucleoprotein complexes, proteins bound to spatially separated sites on a DNA interact with each other by looping out the relatively stiff intervening DNA.
DNA interacts with small molecules, from water to endogenous reactive oxygen and nitrogen species, environmental mutagens and carcinogens, and pharmaceutical anticancer molecules.
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