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The choice of enzyme allows tuning the numbers of sites assayed, while read labeling by attachment of short DNA identifying sequences known as multiplex identifiers (MIDs), or "bar codes" allows tuning the depth of coverage according to the number of individuals pooled in the same sequencing reaction.
But by setting up the right infrastructure — collecting and sequencing patient DNA, identifying patients who could benefit from a particular drug and aggressively recruiting patients for trials — the academic medical centers hope to play a bigger role in the development of new drugs, which could lead to lucrative patent royalties.
They also examined their DNA, identifying seven genetic variants associated with telomere length.
We have now compared activities of these enzymes on telomeric substrates bearing G4 DNA, identifying non-overlapping functions that provide mechanistic insight into the distinct telomeric phenotypes caused by their deficiencies.
Apollo software was used to confirm the protein sequence accuracy by transcribing, and translating the DNA, identifying untranslated regions (UTR), translation start, exons, introns, and translation stops.
I also showed that the mutagenic DNA adduct O-methylguanine (OmG) is repaired without removing the guanine from DNA, identifying a surprising mechanism by which the methyl group is transferred to a residue in the repair protein itself.
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A child's finger bone, mined for DNA, identified an entire species of hominin, Denison man.
Matzas, M. et al. High-fidelity gene synthesis by retrieval of sequence-verified DNA identified using high-throughput pyrosequencing.
Single-molecule, real-time sequencing of BAC clones and nanopore sequencing of genomic DNA identified two repeat configurations in SAMD12.
When their conviction was overturned – DNA identified the real rapist – he doubled down, branding the apology and payout to them the "heist of the century".
Baker, who recently established a database of whale, dolphin, and porpoise DNA, identified the meat as sei, the fourth largest of the baleen whales.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com