Interestingly, Drosophila mutants in DNA repair functions, including mei-41, disrupt receptor tyrosine kinase (EGFR) signaling and results in oocyte polarity defects [ 42, 43].
DNA is the proven primary target of cisplatin, and cisplatin adduct formation effects many DNA-dependent cellular functions, including inhibition of replication and transcription, cell cycle arrest, and DNA damage leading to cell death and apoptosis, but may also result in mutations [3], [4], [5], [6].
According to the gene ontology database http://amigo.geneontology.org/cgi-bin/amigo/go.cgi, the GO annotation of DNA metabolism includes a suite of molecular functions including: DNA replication, elongation, ligation, maintenance, mutagenesis, repair, modification and packaging.
This structure serves as an architectural skeleton to the nucleus and provides support for chromatin organization and various nuclear functions including DNA replication, transcription and DNA repair [ 8].
Proteins are responsible for a huge range of biological functions, including DNA replication and digestion – and protein crystallography is an essential tool for understanding protein structure.
Vitamin B6 (VB6) plays an essential role as a coenzyme in various cellular metabolic functions, including DNA biosynthesis for cellular growth and proliferation.
PML bodies belong to the nuclear matrix, an ill-defined super-structure of the nucleus proposed to anchor and regulate many nuclear functions, including DNA replication, transcription, or epigenetic silencing.
Put together, our findings reveal a systematic loss of control by the host leukocytes over key cellular functions, including DNA synthesis, mitotic exit and self-repair response.
BRCA1 plays a multifunctional role and has been implicated in many normal cellular functions, including DNA damage response, transcriptional regulation, cell-cycle checkpoint control, and ubiquitination.
However, additional studies, including genome-wide analyses, have revealed that E2F factors modulate a plethora of cellular functions, including DNA replication and repair, apoptosis, signal transduction, and metabolism [1], [2].
