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With increasing evidence for Z-DNA formation in vivo and for Z-DNA function, we have revisited the question of Z-DNA in the context of chromatin using tools that have become available since the first studies on the issue.

Finally, and I think not coincidentally, eukaryotes typically have genomes that are greatly expanded in length by as much as several orders of magnitude beyond those of bacteria, and those genomes usually contain a lot more noncoding DNA whose function we don't understand.

Because the register of the dimerization element with respect to DNA-binding domain can greatly affect DNA-binding function, we also constructed two derivatives of the bZIP-like Arnt-C/EBP that altered the register of the C/EBP zipper with respect to the Arnt basic region: the last Leu112 and Ser113 in Helix 1 were removed in one derivative, and Ser113 removed in another.

This concept has been extended in recent years to a more complex understanding of mitochondrial metabolism and mitochondrial DNA function in aging [67].

Star-traveling species could be presumed to have a sophisticated knowledge of genetics and DNA function and therefore would not necessarily bear the form that evolution on a native planet had given them.

Using a transgenic approach, it was possible to resurrect DNA function in transgenic mice.

In conclusion, instabilities observed in B-CLL patients seem to be neutral to DNA function and likely do not contribute to the tumor development.

To assess the functional consequences of changes to a genome, a variety of methods are needed to examine extinct DNA function.

While other studies have examined extinct coding DNA function in vitro, this is the first example of the restoration of extinct non-coding DNA and examination of its function in vivo.

Histones have the basic DNA-binding proteins that control multiple aspects of DNA function [ 14].

Epigenetics broadly defines the study of changes that affect DNA function without altering the nucleotide sequence.

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