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Two typical epigenetic modifications with great influence on DNA function are well known, DNA methylation and histone modification.
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These results were expected since one of the DNA functions is to prevent disruptive changes, which can compromise the integrity of the organism.
Mutants defective in DNA primase function are usually associated with DNA synthesis impairment and S phase delay (Longhese et al., 1993).
Normal cells with noncompromised DNA damage checkpoint function are expected to react to persistent DNA damage by induction of a senescence or apoptosis programme.
These all go well beyond the notion of a gene as a piece of DNA whose function is to produce a protein.
This DNA repair function was originally suggested by Eder and colleagues (Eder et al., 1993).
The DNA Polymorphism function was used to determine the nucleotide diversity (π, [ 90]) for each position in the two alignments.
The gap-containing dsDNA were produced in vitro, and the DNA packaging function was assayed in agarose gel electrophoresis using the defined in vitro phi29 assembly system.
Given such clinical results, understanding the underlying mechanism(s) of how DNA vaccines function is remains as a key step for its success.
The conservation of features of the putative DNA binding domain across species again emphasizes the evolution of the protein from the core sequence and it is important to test if the DNA binding function is also retained.
DNA methylation and centromere function are further linked by the recent finding that DNMT3B interacts with the constitutive centromere protein CENP-C.
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