During condensation and denaturation, the size was decreased by a factor of 8 10, with calf thymus DNA forming spherical globules while plasmid DNA exhibited a toroid-like conformation.
The complexes bind DNA forming intrastrand and interstrand cross-links in one DNA molecule in the absence of proteins.
We have shown previously that tau protein binds to DNA forming beads-on-a-string complexes [21] and represses the disassociation of the double strand as well as improves DNA annealing [22].
Additional histones are wrapped by successive sections of DNA, forming a series of nucleosomes like beads on a string.
DNA clumps Acetaldehyde has also been shown to bind to DNA, forming clumps called adducts.
The polymers were found to self-assemble electrostatically with plasmid DNA, forming nanometer-scale complexes.
Here, the authors fabricated resonators fully composed of DNA forming bundles between microfabricated pillars to study the vibration property of the DNA bundles with/without intercalant molecules.
Kuzyk and co have used this process to bind nine gold nanoparticles just 10nm across to strands of DNA, forming a helical shape.
Then they attached polystyrene molecules to the dendrimerlike DNA, forming a hybrid molecule called an amphiphile -- a molecule that both likes and hates water.
It was also proven to efficiently interact and condense plasmid DNA, forming a stable, small (∼100 nm) and positively charged (+28.6 mV) complex.
Furthermore, it was able to significantly trigger apoptosis, to up-regulate p53, to block cells in the G2/M phase of the cell cycle and, finally, to slightly bind to DNA forming interstrand cross-links (ISCL).
