Sentence examples for dna expression patterns from inspiring English sources

The molecular profiling of DNA expression patterns, RNA expression patterns or protein expression patterns in patient samples is not sufficient for implicating these molecules or molecular mechanisms as therapeutic targets.

13 The epigenetic state of an individual's DNA is both inherited and modifiable, such that DNA expression patterns can be passed from parent to offspring or they can be modified in response to environmental triggers.

The second phase is molecular fingerprinting, which correlates the genomic state, the complementary DNA expression pattern, and the protein repertoire with the functional status of the cells or tissue.

In this study, we generated induced pluripotent stem cells (iPSCs) from AML patient samples harboring MLL rearrangements and found that they retained leukemic mutations but reset leukemic DNA methylation/gene expression patterns.

AML-iPSCs lacked leukemic potential, but when differentiated into hematopoietic cells, they reacquired the ability to give rise to leukemia in vivo and reestablished leukemic DNA methylation/gene expression patterns, including an aberrant MLL signature.

Even though noncoding DNA in the transcriptomes could stem from the contamination with genomic DNA, the expression pattern is highly similar between two independently processed biological replicates of placenta and it is therefore unlikely to be artifactual.

F1 embryos from injections with fgf24 EGFP BAC 37 DNA showed GFP expression patterns almost identical to those from injections with full length fgf24 EGFP BAC DNA that had the iTol2 cassette introduced by GalK mediated recombination (5, Gembu Abe, Koichi Kawakami unpublished observations).

Analyses of OrfQ protein synthesis, stability and localization (in bacterial and/or host cells), and effects of OrfQ and its component domains on DNA methylation, gene expression patterns or chromosome (chromatin) dynamics may give valuable insights into bacterial growth and/or interaction with host tissues or disease.

However, the tumor cells must have changes in DNA or mRNA expression patterns that distinguish them from the surrounding hematopoietic cells.

GRASP and TSPYL5 were selected based on their consistent DNA methylation and expression patterns in tumor, precursor and normal tissues, as well as no significant influence of CNVs and miRNAs on their functions.

Support for the idea that chemoprevention strategies can be successful comes from the study of patients with genetically determined hyperhomocysteinemia where treatment by folate supplementation can restore the normal DNA methylation and expression patterns of specific genes (Ingrosso et al, 2003).