The molecular profiling of DNA expression patterns, RNA expression patterns or protein expression patterns in patient samples is not sufficient for implicating these molecules or molecular mechanisms as therapeutic targets.
13 The epigenetic state of an individual's DNA is both inherited and modifiable, such that DNA expression patterns can be passed from parent to offspring or they can be modified in response to environmental triggers.
Even though noncoding DNA in the transcriptomes could stem from the contamination with genomic DNA, the expression pattern is highly similar between two independently processed biological replicates of placenta and it is therefore unlikely to be artifactual.
In this study, we generated induced pluripotent stem cells (iPSCs) from AML patient samples harboring MLL rearrangements and found that they retained leukemic mutations but reset leukemic DNA methylation/gene expression patterns.
AML-iPSCs lacked leukemic potential, but when differentiated into hematopoietic cells, they reacquired the ability to give rise to leukemia in vivo and reestablished leukemic DNA methylation/gene expression patterns, including an aberrant MLL signature.
AML-iPSCs lacked leukemic potential, but when differentiated into hematopoietic cells, they reacquired the ability to give rise to leukemia in vivo and reestablished leukemic DNA methylation/gene expression patterns, including an aberrant MLL signature.
This DNA damage-specific expression pattern of ∼600 ORFs varies markedly from the expression pattern produced by exogenous exposure to the alkyating agent MMS.
We, therefore, have investigated the role of DNA binding and expression pattern of AP-1 in esophageal cancer with or without HPV infection.
We previously reported that TCRα LCR DNA supports a gene expression pattern that mimics proper thymus-stage, TCRα gene-like developmental regulation.
A very small minority indicated that raw data should be available to participants (e.g., the DNA sequence or mRNA expression pattern) (n = 8, 11%).
