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Thus, MORCs join a growing group of eukaryotic chromatin-modifying enzymes, such as DNA methylases, SWI/SNF ATPases and the HIRAN domain that might have emerged from RM systems and other comparable mobile DNA elements of bacteria [ 5, 20].
Møller, H. D. et al. Circular DNA elements of chromosomal origin are common in healthy human somatic tissue.
Methylation histograms were compiled to assess the distribution of methylation on different DNA elements of interest.
These findings provide new insights as to how SWR1 recognizes histone and DNA elements of a canonical nucleosome.
Many DNA elements of various types have been mapped and annotated, with the objective to establish interactions [ 12].
Together, this analysis supports the hypothesis that DNA elements of the TNR govern expansions similarly in vitro and in vivo.
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To determine whether pSTAT1 binds directly to this GAS DNA element of the survivin promoter, we synthesized oligonucleotides containing this GAS element and made a double-stranded probe.
The major DNA element of human centromeres is alpha satellite, a 171 bp repeat that is tandemly organized either as multimeric, higher–order repeat (HOR) arrays or as heterogeneous monomers lacking periodicity or hierarchy (monomeric alpha satellite) [11].
FOXO3a binds to the FOXO3a DNA element of the DNMT3B promoter to repress DNMT3B transcription.
It is plausible that FOXO3a binds to the FOXO3a DNA element of the DNMT3B promoter to repress DNMT3B expression.
Miz1 acts as a transcriptional activator via the recruitment of the cofactors p300 [ 31] and nucleophosmin [ 47], and it binds to the initiator DNA element of target gene promoters via its central zinc-finger DNA-binding domain.
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