Exact(9)
By identifying DNA elements involved in these sequence-specific interactions, it will be possible to scan hits from psoriasis GWASs to identify variants that disrupt or engender such elements, potentially identifying sites at which allele-specific TF binding takes place to influence psoriasis risk [29,30].
Chimeric ITRs narrowed the DNA elements involved in specificity to the spacer and nicking stem sequences (Fig. 1B).
This ITR appears to be universally replicated by every Rep in this assay due to the exclusion of DNA elements involved in protein specificity.
In both cases, the DNA elements involved are altering chromatin conditions locally, thereby limiting a global long-range silencing mechanism; in other words, they are establishing a boundary.
It has been argued that a minimum NTS size is necessary for the maintenance of 5S rDNA repeats in the genome [ 43] because the NTSs could contain DNA elements involved in the regulation of 5S rRNA gene expression [ 44, 45].
XCI is a classic paradigm of epigenetic silencing, but while many of the molecular players in the inactivation process have been elucidated (Wutz 2011), less is known about the cis-acting DNA elements involved in the spread of silencing.
Similar(51)
Thus, WEMSA provides an attractive option to classical EMSA as a method for the identification of transcription factors and their cognate DNA binding elements involved in regulating gene expression.
Enhancers are DNA elements directly involved in the regulation of gene expression.
Thus DNA elements are involved in genetically specifying centromere placement; however, some regional centromeres are associated with unique DNA sequences.
As the same evolutionary forces and selection mechanisms are not acting ubiquitously throughout the genome, it is feasible that the regions of intergenic conservation may correspond to conserved functional DNA elements, possibly involved in regulation of transcription.
Unequal intrastrand homologous recombination between LTRs of different elements belonging to the same family is a typical example and can result in a net loss of the DNA in between the elements involved.
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