Sentence examples for dna discrimination from inspiring English sources

Vincent is a "free man," an ironic surname given the gene-obsessed world into which he is born, one that legally prohibits DNA discrimination but practices it proficiently nonetheless.

Since double-stranded DNA is present at much higher concentrations than gapped DNA in vivo, a mechanism of double-stranded DNA discrimination is required.

The quantification of fetal DNA by methylation-based DNA discrimination has been used for the NIPT of fetal T21 and promising results have been reported [ 16- 18].

However, in the case of the Y271A mutant, although gapped DNA discrimination was similar to that of the wild-type enzyme, a high degree of gapped DNA enhancement was also observed when the substrates were either of the C10 S BPDE-adducts (dA and dG).

The accurate quantification of fetal-specific EPs by methylation-based DNA discrimination is of critical importance in the NIPT of fetal T21 using EPs, because such fetal-specific EPs on chromosome 21 are used in the detection of fetal T21 by direct comparison with a placenta-derived DNA methylation marker on a reference chromosome.

DNA sequence discrimination by CAP derives both from sequence-dependent distortion of the DNA helix and from direct hydrogen-bonding interactions between three protein side chains and the exposed edges of three base pairs in the major groove of the DNA.

However, for those deletions and insertions for which this extension resulted in the same nucleotide as was present in the wild-type DNA, optimal discrimination was achieved by oligonucleotides extending further into the deletion or insertion.

DNA polymerase discrimination against errors during DNA synthesis depends on direct minor groove interactions of the protein with the DNA primer template, and disruptions in N3 purine and O-pyrimidine atom positioning decreases polymerase fidelity (reviewed in Kunkel and Bebenek 2000).

Because the residues from this loop have been shown to be important for interrogation of DNA during discrimination of modified versus unmodified nucleobases prior to base flipping, a different mode of intercalation would likely alter the mechanism by which each enzyme locates its 5mC target.

An artificial mimic was engineered with the TaqMan® probe site replaced by a larger irrelevant DNA fragment allowing discrimination from ASFV by using two-colour TaqMan® probe reporters.

In this study, we applied two stringency control strategies for surface plasmon resonance (SPR) detection of DNA hybridization and discrimination of completely and partially complementary 24-mer sequences.