Sentence examples for dna determinants from inspiring English sources

The DNA determinants of binding by AncSR1+RH are very different.

The evolutionary effect of the RH substitutions was to erase all major ancestral DNA determinants of affinity and to establish novel determinants, both main and epistatic.

We used these data to quantify the DNA determinants of TF affinity for each intermediate protein using the linear model described above.

10.7554/eLife.07864.006 Figure 4. Epistasis across the protein-DNA interface: effect of historical replacements in the TF on DNA determinants of affinity in the RE.

Although replacement glu25GLY increases affinity for all REs, it does not do so uniformly: it increases relative affinity for REs with nucleotide states A3, A4 and G3xA4 thus specifically improving relative binding to SREs and decreases relative affinity for REs containing the ancestral DNA determinants G3 and T4, as well as the ERE-specific combination G3xT4.

Nucleotides+4, +6 and+8 (+1, −2 and −4 on the opposite strand) are placed close to the 100-122 loop and the helices α3/α4 (Figure 5C) consistent with the strong DNA cleavage determinants observed at these positions for pneumococcal topo IV [15].

Synthetic CpG islands reveal DNA sequence determinants of chromatin structure.

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One is that cenH3 nucleosomes are actively recruited by other factors or processes (Foltz et al. 2006), although this begs the question of how the recruiters are themselves recruited if there are no DNA sequence determinants.

In order to ask how this local heterogeneity translates into an unmethylated state and if different mechanisms function in different parts of islands, we inserted fragments of CGIs to define their individual potency to regulate methylation and to potentially identify DNA sequence determinants of this regulation.

We found that ComA binds a degenerate tripartite sequence consisting of three DNA-binding determinants or "recognition elements".