Sentence examples for dna defect from inspiring English sources

Neuropathological findings in mitochondrial DNA disease vary and are often dependent on the type of mitochondrial DNA defect.

Ethical questions of a different kind are raised by the possible application of PGD for disorders caused by a mitochondrial DNA defect.

Another is gene therapy to correct some of the underlying DNA defects.

More than 700 oncology drugs are now in development, many aimed at DNA defects, Dr. Pao said, "and the number will only accelerate".

However, in the cases where mitochondrial DNA defects are present, the use of allo- and xeno-genetic mitochondria would be more appropriate.

In selective cases, such as in patients with sporadic form or in whom molecular investigations result unable to demonstrate DNA defects, nerve biopsy might give relevant information for diagnosis and differential diagnosis.

Once the nuclei enter mitosis, however, DNA defects activate a Chk2-dependent checkpoint that inactivates the centrosome and disrupts mitotic spindle function [7], [8].

These categories are perfectly in line with the reduced proliferation potential, accumulation of DNA defects and changes in cellular cytoskeleton as reflected by the senescence phenotype that was observed morphologically.

Considering radiation-induced DNA defects, amplified DNA is highly radiosensitive.

The DDR pathway detects and corrects DNA defects.

Nuclease-based gene editing is a powerful technology to correct DNA defects (Box 1).