DNA-related metabolic processes including transcription, recombination, DNA repair and replication, are coordinated by functionally distinct chromatin domains spatially arranged within a precisely defined nuclear architecture [39].
The low-affinity nickel site present only in the NikR structure without DNA, site type 5, is also coordinated by a histidine, specifically H123.
In crystal structures of APE1 DNA Mn2+ and APE1 DNA Mg2+ complexes, Mn2+ and Mg2+ are both coordinated by E96 and the DNA product, and in APE1 Mg2+ and APE1 Mn2+ structures, the metals are coordinated by D70 and E96.
MSSP-1 possesses versatile functions including stimulation of DNA replication, transcriptional regulation, apoptosis induction and cell transformation coordinated by c-Myc (Niki et al, 2000).
Ancient DNA work and phylogenetic analyses were performed by K.J.M. and coordinated by A.C. Radiocarbon data were obtained and analysed by T.H., T.D. and D.C. at the ORAU, and J.v.d.P. at the CIO, while C.T. and T.H. undertook age modelling.
This regulation is tightly coordinated by a number of mechanisms, such as DNA methylation [ 3]; chromatin organization [ 4]; dimerization; and sequence-specific DNA binding, which is executed primarily by transcription factors (TFs).
Gene expression is coordinated by complex regulatory mechanisms that involve transcription factor binding and chromatin modification including DNA methylation.
The Human Genome Project, coordinated by the U.S. Department of Energy and the National Institutes of Health, has already unraveled more than 80% of the genetic code in human DNA.
They are coordinated by design.
Swimming is coordinated by the nervous system.
