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When these two DNA probes are in close proximity, the DNA can interact through a subsequent addition of two other circle-forming DNA oligonucleotides.
As with pH-dependent unfolding, the −OH group in thermally unfolded DNA can interact with water molecules, facilitating the unfolding of iMs at lower temperatures.
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The mungbean VrDhn1, a Y2K-type DHN, can interact with DNA (Lin et al. 2012).
For example, DNA methylation can prevent binding of some transcriptional activators to their specific DNA sequences; furthermore, methyl-DNA binding proteins can recruit repressor complexes thus interfering with transcriptional initiation; moreover, DNA methyltransferases can interact with histone deacetylases rendering histones hypoacetylated.
When the PLA probes are in close proximity (< 40 nm), the DNA strands can interact through a subsequent addition of two other circle-forming DNA oligonucleotides.
Here we examine whether a membrane-spanning DNA nanopore can interact with cancer cells and potentially trigger cell death.
In DNA, transposable elements can interact with DNA-binding proteins to change the transcription of nearby genes, and in RNA, they can change the structure of RNA, influence 3′ end processing, or mRNA localization or translation [ 3].
Molecular docking study revealed that compound 16 cannot intercalate into regularly stacked base-pairs of DNA duplex but can interact or intercalate to topo IIα-bound DNA.
Together, this study demonstrates how genetic (SNPs) and epigenetic (DNA methylation) mechanisms can interact and our data provide a possible molecular mechanism through which type 2 diabetes-associated SNPs that introduce or remove CpG sites may affect gene function through differential DNA methylation and consequently the phenotype of the disease.
Interestingly, several studies have indicated that poly- ADP-ribose) poly- ADP-riboseRpoly- ADP-ribosepolymerasengle-stranded DNA break repair gene, can interact with the DNA binding domain of progesterone receptor.
Despite high similarity in overall structure between HMG-boxes, individual domains exhibit distinct DNA binding characteristics as discussed above, and can interact with DNA in different orientations.
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