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Current DNA based methodologies generally suffer from nucleotide substitution bias that preferentially mutate particular base pairs or show significant bias with respect to transitions or transversions.
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Our data suggest that until such nucleic acid based methodologies are available, identifying MAP DNA prior to, and its clearance following initiation of antiMAP therapy, may provide the most readily available practicable surrogate to in vitro MAP antibiotic susceptibility information.
I have characterized the binding of many selected aptamers using UV crosslinking and EMSA based methodologies and have identified that a majority of our selected HSF1 aptamers bind to the DNA Binding domain and Trimerization domain.
Regression and network based methodologies were used.
These three programs were formulated using evidence based methodologies.
An alternative methodology to CGH is the multiplex amplifiable probe hybridization (MAPH) methodology, a DNA based method that allows the accurate and reliable determination of changes in copy number in "known" or "unknown locations" in the human genome.
There are limitations with the anchor based methodology.
Prenatal diagnosis for PAH deficiency is only available using DNA-based methodologies.
This research focuses on further developing DNA-based methodologies to mimic digital data manipulation.
Among these, DNA-based methodologies are one the most promising approaches since they provide very precise tools, and due to their robustness, they can be applied to all the different life stages of marine species.
Unlike culture-based methods, the detection of bacteria in clinical samples by DNA-based methodologies does not indicate whether the bacteria in question are viable.
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