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In this model, the transformation pilus would directly capture DNA, and with the help of a retraction ATPase, pull the DNA through the cell wall to hand it over to ComEA in the cytoplasmic membrane (Fig. 3).
That's good for science, but it means that anyone with the capacity to synthesise DNA and with less benevolent motives than Venter and his colleagues could use this information maliciously, to make new and deadly infectious organisms.
As the narrative expands into the next generations there is a terrible tension about which pieces of Milo's mind – mathematical brilliance, navigational knack, addictive personality – have been bequeathed by each division of his DNA, and with what consequences for those who receive them.
The latter is predicted to interact with short conserved regions of the target DNA and with the RNA polymerase.
To optimize the specificity and sensitivity of the biosensor, the LAMP parameters were investigated under varying isothermal conditions using varying concentrations of reagents and target DNA, and with different combinations of newly designed loop primers.
The mechanisms involved in their polymerisation activity have been elucidated based on structural analyses of the DNA polymerase of bacteriophage RB69 crystallized under different conformations, i.e. the enzyme alone or in complex with DNA and with both DNA and incoming nucleotide.
Similar(28)
Priming with DNA and boosting with protein has also proven successful.
It has been proposed that DXR exerts antitumor activity by interacting with DNA and interfering with its metabolism [19].
Priming with DNA and boosting with polypeptide is another new and promising approach.
For example, 1 fM DNA measured with 2.1 × 10 beads would result in 619 beads with 3 DNA, 44 with 4 DNA, and 2 with 5 DNA.
The carcinogens interact with the DNA and interfere with its normal function.
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