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We propose that stem cells located in the IBL give rise to differentiating daughters through asymmetric divisions in response to cues from the underlying basement membrane.
These cells are diploid and clonogenic and undergo sustained symmetrical self-renewal divisions in response to FGF2 and EGF independent from any specific cellular niche.
Therefore, the excessive number of cell divisions in response to haematopoietic demands after irradiation probably promotes the ageing of surviving HSCs.
Several recent studies in the hematopoietic stem cell system have shown the utility of single-cell time-lapse imaging to delineate symmetric and asymmetric divisions in response to extrinsic and intrinsic stimuli and cell fate choice instructed by cytokines.
Our histological analysis during root-primordia initiation in two carnation cultivars confirmed that some cambial cells located between the phloem and xylem activate formative (periclinal) divisions in response to the endogenous auxin signal.
Lotus HK 1 (LHK1) is a member of the cytokinin receptor family and plays a crucial role in initiating cortical cell divisions in response to rhizobial signaling; this gene was located on chr 4 (chr4.CM0042.1660.nc), with a highly conserved paralog on chr 2 (chr2.LjB11M03.80.nc).
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The mechanism of Mycobacterium tuberculosis shift between the latent and active state is not clearly understood, but one of the essential components of these kind of systems is the regulation of cell wall synthesis and cell division in response to stimuli from the host via signal transduction.
The SOS response in E. coli has long been known to cause an inhibition of bacterial cell division in response to DNA damage.
One interpretation of our results is that Fz and Vang can act independently of one another in SOPs to orient asymmetric division in response to extrinsic PCP cues.
These data demonstrate that growth factor treatment and in particular oncogenic BRAFV600E induces the uncoupling of LKB1-AMPKα complexes providing at the same time a possible mechanism in cell proliferation that engages cell growth and cell division in response to mitogenic stimuli and resistance to low energy conditions in tumor cells.
It is not known whether delayed GSC division in response to aging requires normal niche architecture.
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