By contrast, putting a gun to MPs' heads will surely sow division, trigger resignations and risk opening up the sort of bitter splits on Europe that – as history shows – are bad for the Tory Party and, most crucially, Britain".
Asymmetrical cell divisions trigger differences in lineage choice of progeny cells or can separate a daughter cell with self-renewal capacity from one that proceeds to differentiate [ 12, 13].
The question then becomes, what is regulating Swi6 activity, and what triggers cell division initiation?
As in mitosis, the first meiotic division is triggered by separase, whose cleavage of Rec8 along chromosome arms destroys the cohesion holding bivalents together, and triggers disjunction to opposite poles of pairs of chromatids attached to maternal and paternal kinetochores, respectively [ 33].
To halt cell division or trigger cell suicide, p53 needs to regulate the activity of various genes, which requires that it first bind to the DNA of the genes' regulatory sequences.
Many researchers were interested in understanding how an enzyme called telomerase replenishes telomeres, which would otherwise shorten with each cell division, eventually triggering senescence (see "More Than a Sum of Our Cells").
Peptides that prevent microtubule disassembly can interrupt mitosis, prevent cell division, and trigger apoptosis.
A related effect was observed in diverse host-phage systems, including the T4-like phages, with β-lactam and quinolone antibiotics, as well as mitomycin C. A common characteristic of these antibiotics is that they inhibit bacterial cell division and trigger the SOS system.
Binding disrupts the microtubule dynamics by stabilizing microtubules and inducing microtubule bundles, thereby inhibiting cell division and triggering apoptosis [ 38].
Secondly, the model in [ 32] lets division be triggered by active mass rather than total mass reaching a threshold.
Recent evidence suggests that oncogene-driven cell division cycles trigger the activation of DNA-damage response in the early stages of tumorigenesis (Bartkova et al, 2005).
