The Register article stated that the division was about to undergo a major change in focus resulting in a huge restructuring of the workforce.
After being generated from phialides through repeated asymmetric mitotic cell divisions, conidia need to undergo a maturation process to enable the long-term viability [9].
Accordingly, if one were to track the behaviors of a population of stem cells in a tissue, one would observe that many undergo a small number of divisions before being absorbed into the pool of differentiated cells, whereas a subset seems to undergo division for a very long time without all differentiating.
It has been demonstrated that this pathological process is dependent on the ability of the mitochondria to undergo division as this allows the equal redistribution of mitochondria during cell proliferation.
When a cell arises from the fusion of the pronuclei or from a division, it is "predestined" to undergo one of three developmental fates: it will divide, it will die off, or it will reach its final differentiated cell type.
Classical analysis of cell division cycle yeast mutants revealed that cells prevented to undergo cell division due to loss of cyclin-dependent kinase activity continue to synthesize proteins and grow to a larger size (Hartwell et al. 1973; Nurse et al. 1976; Reed 1980; Dickinson 1981; Goranov et al. 2009).
Next, we extracted total 29 sets of sibling cells from which one termed h-cell differentiated to heterocyst without further cell division, while the other termed v-cell remained to be vegetative to undergo cell division from the lineage shown in Figure S2A (24 sets termed group A, microchambers) and S2C (5 sets termed group B, solid media).
The authors posited that this correlation indicates a coupling of L1-mediated retrotransposition to cell division, as transcripts highly expressed during cell division would be more likely to undergo retrotransposition.
Importantly, EC division phenotype is also seen when ecdysone signaling is perturbed in the soma only: Tai downregulation and Ab upregulation in the somatic cells similarly stimulated normally quiescent ECs to undergo divisions.
These cells may return to the VZ or ISVZ to undergo cell division, but Ki67 expression clearly demonstrates that cell division also occurs throughout the OSVZ.
