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Many of these issues are often corrected at later sampling times, when constraints on division timing and the presence of new information allows the model to correct previous mis-assignments.
One might expect that due to metabolic noise, cell division timing should become progressively less predictable as development proceeds; such time-dependent decorrelation has indeed been noted in an early study of spiralian cell lineage [37].
Indeed, both cell division timing and histone modifications have been shown to affect cell fate decision in preimplantation embryos (Zernicka-Goetz, 2006).
In mammalian preimplantation embryos, cell division timing appeared to associate with cell fate choices (Chazaud and Yamanaka, 2016; Zernicka-Goetz, 2006).
Such persistent correlation of division timing among distantly related cells might reflect intercellular coupling of cell cycle progression.
This round of divisions is led by 3c11 around 800 830 minutes after first cleavage (Figure 17); the subsequent division timing of 3d11 and the 3cd12 pair was not accurately determined, but all divisions were completed within the next 50 minutes.
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Can time-lapse analysis of cell division timings [morphokinetics (MK)] in mouse embryos detect toxins at concentrations that do not affect blastocyst formation?
Cell division timings were determined manually and included t2, t3, t4, t5, t6, t7 and t8 (time from thawing to 2, 3, 4, 5, 6, 7 and 8 cells), time of compaction, tM, time to formation of a blastocoel, tB and time to an expanded blastocyst (tEB).
The "properties" include not only viability-inviability of the strains but also average size of cells at division, relative timing of bud emergence, DNA synthesis and mitosis, and the precise phase of arrest of inviable mutants.
This assay does not directly measure viable spores per meiosis, so values can exceed 4. (D ) Sk/Sp hybrids complete both meiotic divisions with timing similar to that of pure species controls (representative experiment of 3, n ≥200 cells for each data point).
In particular, the coupling of cellular metabolism with cell division determines the timing of the G1/S transition and the overall rate of cell proliferation [12].
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