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Fifty-two patients, whose disease fulfilled CASPAR criteria but had not been included in the JPsA cohort, manifested more enthesitis, sacroiliitis, inflammatory bowel disease and uveitis and less psoriasis.The data support division of patients with JPsA into 2 clinical subgroups, according to age at disease onset.
But in a post on his blog, the Kidney Doctor, Dr. Ajay K. Singh, an influential nephrologist at Brigham & Women's Hospital in Boston, questioned whether the division of patients based on whether they undergo dialysis "makes any sense from a safety perspective".
The expression profile of these 38 probe sets was used to perform a clustering of the 68 tumors and led to the division of patients into two clusters (Fig. 6A).
Our division of patients into groups with increased and decreased summarized SF-36 scores is arguable.
This analysis does not depend upon any a priori division of patients into neglect and non-neglect groups.
The division of patients into multiple risk groups and the late occurrence of many events further burden such trials.
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A further division of patient groups was based on smoking or never-smoking status.
An appropriate sub-division of patients' needs to be applied at diagnosis, patients who would not respond to, for example ATRA/ATO, could be treated with the most suitable therapy based on their clinical and molecular presentation.
Upon sub-division of patients into ER+ and ER− cohorts, this correlation was most significant in the subset of ER+ breast cancer cases (Fig 4), supporting our initial findings that the SPINK1 transcript displayed positive association with poor prognosis predominantly with ER+ cases.
This suggests that the shuffling algorithm indeed does identify biologically or clinically distinct divisions of patients in most cases.
The use of the model yields the relative hazard for each patient, which serves as the linear predictor for survival endpoints and further division of the patients into good and poor prognosis groups based on the linear predictor.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com