The results for the real patient data sets were entirely consistent with those for the synthetic data, as can be seen in Figures 5, 6, and 7 and Tables 1, 2, and 3. We again observed the division of the error estimators in the same four groups according to performance.
The idea is that replication errors surreptitiously record cell divisions, the number of errors being proportional to the number of divisions.
Through the transcriptional regulation of different target genes (PTEN, AMPK, Sestrin 1/2, TSC2) p53 negatively regulates the insulin/IGF-1 and TOR signaling, creating an interpathway network that permits cells to inhibit cell growth and division to avoid the introduction of errors during these processes under stress conditions.
Although it is impossible to observe every division directly, one method for counting divisions is to count replication errors; the greater the number of divisions, the greater the numbers of errors.
In the database used in Kenya, the list of possible villages was predefined, based on administrative divisions, which reduced the risk of errors.
If mutations occur as a result of errors during cell division, the model suggests that a low cellular turnover rate protects both against aging and the development of cancer.
Different possibilities account for the sex-specific differences: first, the differences in the recombination patterns between male and female meiosis; second, more permissive checkpoints in females than males; third, the age-related loss of chromosome cohesion in female gametes; and fourth, the difference in the ability to detect the consequences of meiotic division errors [5], [11] [15], [34].
It gives rise to chromosomal instability, as seen in a high rate of chromosomal division errors.
While the firm, the tax division of law firm DLA Piper, found several types of errors, none of them were substantive, Shalala wrote.
Thus, the rapid maternally driven embryonic divisions were much more sensitive to division errors than were the later zygotic divisions.
