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Within Sox group B, the division into subgroups B1 and B2 has been proposed based on a full-length protein sequence alignment and the functional roles of the group B proteins in chicken [17] and some other vertebrates [12].
SoxB1- and SoxB2-like proteins have also been identified in the cnidarians [18] and demosponges [13], [19], although with much less confidence, which implies that the division into subgroups B1 and B2 might have taken place before the demosponges diverged from the eumetazoans [13].
On the basis of free-text variables, a division into subgroups was performed.
This restricts division into subgroups, and when this is done, marginal effects are difficult to assess.
Second, as the merging routine runs in quadratic time, the computation benefits from the division into subgroups.
18 Skodova et al supplemented with a division into subgroups of patients who improved, were unchanged, or declined.
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Table 1 presents the clinical characteristics of the two reference groups and the study group with division into cancer subgroups.
However, a clear division into 17 subgroups was evident when we created our phylogenetic tree (Fig. 1b and Additional file 3, a rectangular tree has been included in Additional file 4).
To investigate the evolution of the SEO gene family, we studied the distribution and organization of SEO genes in Fabaceae and non- Fabaceae genomes and their phylogenetic division into seven subgroups.
This is consistent with the idea that luminal tumours form a continuum according to the expression levels of proliferation-related genes and that their division into two subgroups is somewhat arbitrary (Desmedt et al, 2008; Wirapati et al, 2008; Colombo et al, 2011).
Treatment decisions are often made through the division of patients into subgroups using biomarkers based on gene expression assays or immunohistochemical assays.
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