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In this model, inspired by the tensegrity concept, each cell is capable of changing its morphology, and performing various cellular processes such as growth, division, death, and polarization.
Assuming reasonable values for the cellular division, death, and mutation rates, there must be at least k = 1000 mutations that confer resistance against only one drug for triple combination therapy to somewhat improve the chances of treatment success.
Differential expression of genes related to antigen processing and presentation [10], chemokines, cytokines and apoptosis [11], as well as extracellular matrix, cell adhesion molecules and molecules involved in cell division, death and transcription [12], have all been reported.
(C2) Time to activation, division, death, and disintegration.
The first model includes explicitly the processes of cell division, death and migration.
Four cellular mechanisms determine tissue shape: cell division, death, shape change and movement.
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The resulting linear 2-dimensional Markov process corresponds to the exponential distribution of the timing of various elementary events (such as cell divisions, death etc).
We use two spatial generalizations of the Moran process, which include cell divisions, death and migration.
To study the selection dynamics in a heterogeneous spatial colony of cells, they use two spatial generalizations of the Moran process, which include cell divisions, death and migration.
As described, the time-to-event model deals with the timing and occurrence of developmental events: divisions, deaths, final differentiation.
The link between cell division and death is critical: if the relative death rate is too high, barrier function diseases may result whereas if division outpaces cell death, epithelia could become neoplastic.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com