Sentence examples for division checkpoints from inspiring English sources

The high rate of cell division error implies that the regulation of mitosis, particularly the activity of cell division checkpoints, might be different from that in somatic cells.

As chromosome abnormality caused by erroneous mitosis can lead to severe consequences, mRNA mediated transient modulation of cell division checkpoints or epigenetic state may represent a possible route to improve the quality of in vitro fertilized mammalian embryos without alteration of the embryo genome.

Therefore, we speculate it may be necessary for cleavage stage embryos to evolve a special cell division checkpoint mechanism, AurkC may be an important member of such mechanism.

Functional analysis of the 225 candidate genes revealed a number of highly enriched mitosis and cell division checkpoint sub-networks (Padjusted = 8.88 × 10−3) (Additional file 2: Table S8).

Overlaid onto these signals that promote orchestrated cell division are checkpoints that ensure appropriate mitotic spindle formation, a lack of DNA damage, kinetochore attachment, and that each daughter cell has the appropriate complement of DNA.

The polo-like kinase (Plk) family of proteins is comprised of five highly conserved serine/threonine protein kinases that have a key role in such cellular processes as cell division and checkpoint regulation of mitosis (Medema et al, 2011).

Besides being an enzyme that catalyzes DNA topology changes [19], [20], [21], [22], topo IIα is also a critical regulator of one G2/M checkpoint during cell division, the decatenation checkpoint [23].

It is widely accepted that carcinogenesis necessitates multiple genetic alterations that either drive cellular division or remove checkpoints regulating this process in normal cells.

Thus, the COC may serve as a model system to study a new class of checkpoints that specialize in monitoring division orientation in multicellular organisms.

Comparison of gene expression profiles of CPCs and non-neoplastic tissues revealed profound alterations in cell cycle regulation and DNA damage responses, suggesting that dysregulation of cell division and DNA checkpoint pathways may represent key vulnerabilities.

The bridge over the Öresund – that televised Scandi-noir icon – which had been a symbol of the borderless peace and prosperity between Denmark and Sweden is now a place of checkpoints and divisions.