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FtsZ assembly in E. coli is inhibited by SulA resulting in a cell division block until damaged DNA is repaired, after which SulA proteolysis restores cell division31.
Dangerous DNA mutations would no longer have undesirable effects due to the cell division block.
In E. coli, cell division block is frequently associated with induction of recA-dependent SOS response [33].
These included suppression of a cellular division block [27], resistance to mitomycin C [28], and resistance to quinolones [29].
On the other hand, there is a much more severe division block under these conditions in the absence of FipA.
Consequently, we investigated other causes of FipA-linked cell division block under oxidative stress, focusing on the interaction of FipA with well-characterized proteins of the divisome.
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