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Apparent clearance (Cl/ F where F is bioavailability) was calculated by dividing dose by AUC0 24 and apparent volume of distribution (Vd/ F) was obtained by dividing Cl/ F by β.
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An initial dose of prednisone or its equivalent of at least 40 60 mg per day as single or divided dose is usually adequate.
Whether lithium dosage regimens, i.e., once-daily vs. divided dose, correlate with polyuria risk is still debated (Gitlin 1999; Carter et al. 2013).
1 mg dose of Bovine insulin is injected subcutaneously in divided dose.
The maintenance TPM-IR dosage of 200 400 mg/day is administered as a divided dose.
before cisplatin, or by divided dose (2 x 0.005-2 x 0.5 mg kg-1 i.v).v
20 The maximum recommended dose of sitagliptin is 100 mg daily in a single or divided dose.
Dose-response information is almost nonexistent; the divided dose problem has not been studied adequately, and very little information is available on interspecies reactions.
Our phase I study has allowed us to increase the dose of melphalan to 1.75 mg kg-1, but we found no pharmacokinetic advantage from divided dose administration.
As prolactin level remained elevated after a further 3 months of treatment, cabergoline dose was increased to 5 mg in a divided dose twice a week.
The higher dose was given as a bolus to Group B (n = 9), and by divided dose to Group C (n = 6).
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