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The genotypes are divided into several subtypes with the number of subtypes depending on the genotype.
Group M is the most widespread and is divided into several subtypes, lettered from A to K. Subtypes have been historically defined by a human-driven crisp clustering obtained by analysing different phylogenetic trees constructed over different HIV genes, but do not necessarily correspond to an optimal grouping under specified constraints.
The M group, which has caused the vast majority of HIV-1 infections worldwide, can be further divided into several subtypes, including A D, F H, J and K, as well as several circulating and unique recombinant forms (CRFs and URFs) [1], [2].
BCCs can be divided into several subtypes on the basis of histopathologic features and biologic behavior.
Each type can be further divided into several subtypes, depending on the underlying causative molecular defect.
Adenocarcinomas of the lung are divided into several subtypes including the BAC and papillary (PAP) types (Travis et al, 1999).
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Based on the presence of specific molecular alterations (oncogenic drivers), NSCLC has been recently divided into several distinct subtypes.
While kidney cancer can be divided into several histological subtypes, the majority of the cases (about 75%) are clear cell renal cell carcinoma (ccRCC) [ 2].
With a growing number of oncogenic drivers being identified in squamous and nonsquamous NSCLC, this malignancy has been recently divided into several distinct subtypes according to the specific molecular alterations.
With a growing number of new oncogenic drivers being identified in squamous and nonsqumous NSCLC, this malignancy has been divided into several distinct subtypes according to the specific molecular alterations.
Based on genomic profiling, breast cancers are divided into several molecularly defined subtypes, including luminal A (ER/PR+, Her2-), luminal B (ER/PR/Her2+), Her2 (mostly Her2 amplified and ER-), normal-breast-like (the highest expression of the genes known to be expressed by adipose tissue and other nonepithelial cell types), and basal-like types (mostly ER-).
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