Sentence examples for divided dose administration from inspiring English sources
Our phase I study has allowed us to increase the dose of melphalan to 1.75 mg kg-1, but we found no pharmacokinetic advantage from divided dose administration.
However, in a study by Shepherd et al, cisplatin was administered in a single dose over a 4-week cycle, and therapeutic effect was superior over divided dose administrations in patients with non-small cell lung cancer.
For administration in divided doses, it is also necessary to administer the subsequent dose after a sufficient period of observation.
Background: Because lovastatin is efficiently extracted by the liver and because its administration in divided doses is associated with increased efficacy, an extended-release (ER) formulation may have the potential for a dose-sparing advantage relative to the immediate-release (IR) formulation in the treatment of hypercholesterolemia.
68 The usual dose in at least 60% of studies was 10 30 mg/kg/day in two divided doses for both oral and intravenous administration.
Solute diuresis and administration of cisplatin in divided doses or as a continuous infusion reduce nephrotoxicity [ 1].
The power of acidification of urine is best estimated by measuring the pH of urine after the administration of ammonium chloride in divided doses over two or three days.
This protocol includes vitamin replacement (vitamins C, E and B complex) and oral administration of diazepam 30-600 mg in divided doses), with gradual taper off over a week.
This route was chosen to ensure compliance in preference to intranasal administration, which would have involved four divided doses over 24 h.
To address the dose-related risk of seizures associated with high peak concentration of the drug following oral administration, bupropion hydrochloride is administered in divided doses or as sustained release dosage forms [ 1, 2, 5, 6].
It examined the hypothesis that daily administration of 1 g of aspirin orally in 2 divided doses to individuals with documented CHD would result in significantly reduced mortality over a three-year period [ 9].
