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Studies with ess1 mutants have proved difficult because they do not follow classic cell-cycle arrest kinetics, as mutant cells can divide up to 7 times prior to arrest and nuclear fragmentation (Hanes et al. 1989).
Arguing against this prediction, however, were observations that our cells have the ability to divide up to 80 times in culture, a number so great that the amount of cancer cells generated would kill the organism long before RS is initiated.
It is known that normal somatic cells can only divide up to a limited number of times (the Hayflick limit) and once this limit is reached, they enter replicative senescence and lose the ability to divide further [ 40, 41][ 7] (chapter 10).
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The spheroids actively divide up-to 50 cells (Figure 4B).
The branches divided up to three times, and some bore terminal clusters of sporangia.
To build it, students worked as an engineering team, dividing up to create the mechanical and electrical parts, sensors, and software.
The hall can be set up to serve 2,000 people at a banquet, or divided up to serve smaller groups.
Divided up to test our language skills, the model frantically grasped at the man in charge, desperately reiterating that she spoke no French.
Wisconsin has 42 delegates, with 18 going to the statewide winner and 24 divided up to the winner in each of the state's eight congressional districts.
The castle's northern wing originally contained a dining hall, but this was later divided up to make more luxurious quarters for the Prince Bishop.
Upon immunization of these mice with ovalbumin and complete Freund's adjuvant (CFA), ova-specific T cells inside draining lymph nodes divided up to five times within 2 days (Figure 7C 7E; Figure S6A).
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