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In order to maintain their unlimited capacity to divide, stem cells require controlled temporal and spatial protein expression.
When "choosing" whether or not to exit the quiescent state and divide, stem cells integrate a variety of local and systemic signals (reviewed in Drummond-Barbosa, 2008; Morrison and Spradling, 2008).
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Are actively dividing stem cells more likely to undergo lineage commitment than quiescent stem cells?
As the majority of GFP+ cells in the DT+dox SVZ are not GFAP+, a marker of postnatal semiquiescent stem cells (Doetsch et al, 1999), enhanced GLI1 levels could thus increase the number of actively dividing stem cells.
The Wnt target gene Lgr5 marks actively dividing stem cells in Wnt-driven, continuously self-renewing tissues such as small intestine and colon (Barker et al, 2007), stomach (Barker et al, 2010) and hair follicles (Jaks et al, 2008).
Within the SVZ, dividing stem cells gives rise to neural progenitor cells (NPCs) [ 28], which normally travel along the rostral migratory stream to the olfactory bulb where they differentiate into inhibitory interneurons [ 29].
Indeed, two populations of dividing stem cells were observed: those with a mitotic spindle perpendicular (∼90°) to the basement membrane and those with a mitotic spindle parallel (∼10°) to the basement membrane.
To a great extent, this racial divide stems directly from racial prejudice.
The surge is helping to close a looming digital divide stemming from the high cost of in-home Internet access, which can be prohibitive for some.
St . Louiss geographic divide stems from a legacy of segregation — legal and illegal — and more recent economic stratification that has had the effect of reinforcing racial separation.
But standing behind this sharp Turkish reaction to Israel's assault on the Turkish ship is a deeper regional rift, and this divide stems from the near-universal conviction that the Israeli-Palestinian "peace process" has failed.
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