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To adapt to this diversity of variation among individual tumors, we developed an adjustable multi-component model to detect aberrations, the first core feature of RAE.
To adapt to the diversity of variation among individual probes, samples and alterations, we developed and validated a multi-component scoring scheme for the detection of copy-number changes on a large repository of suspected CLL samples.
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In contrast, a geographic cline in Cf-2 homolog diversity was consistent with a cline in diversity of neutral variation in natural populations of Solanum pimpinellifolium [17].
Understanding the diversity of genome variation using comparative genomics requires a bioinformatics approach that can be tailored and modified by the end user.
We previously genotyped tagging SNPs (which capture the majority of diversity of genetic variation across a region) across the STS gene, with an evidence of association around intron 1 and 2 [Brookes et al., 2008].
The data themselves also present numerous challenges because of the laboratory methods by which they are extracted [ 29], the complex informatics procedures by which they are assembled [ 28, 30], and the diversity of molecular variation at the level of expression that they reflect (e.g. alternative splice variants; [ 29]).
Twenty-one morphological landmarks were plotted on each photograph (Fig. S1); the coordinates of those landmarks were imported into the software TPSRELW (Rohlf 2006), which was used to identify diversity of shape variation within and between the crosses and treatments, independent of body size.
Recent studies have confirmed that RNA editing [36], [37] and non-template extension [26] are common post-transcriptional modifications, and these mechanisms could account for the wide diversity of sequence variations observed in mature EBV miRNA.
However the diversity of land variations, such as topography, is also important.
Replication by these viruses is termed low fidelity because RNA mutations, due to imprecision in the replication processes, lead to a wide diversity of genetic variations in progeny.
Because these resources were generated using Sanger sequencing, they were relatively expensive to produce, but despite the cost have insufficient depth to capture the diversity of splicing variations in human cells.
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