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The different layers of diversity of signalling that give rise to the multiple functions of the IGF/INS axis are schematically shown in Figure 1 and explained in the following chapters.
The versatile diversity of signalling associated with ubiquitination further stems from the myriad ways in which the polyubiquitin chains can be formed, either as uniform (e.g. containing only Lysine 48 or 63 linkages) or as recently discovered atypical branched chains with mixed linkages (e.g. Lysine 6/27/48-linked chains [ 7]), which seem to serve distinct context-specific functions.
The diversity of signalling cascades identified in RAGE-mediated cellular signalling implies that different RAGE ligands might induce different pathways, especially in different cell types.
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Advances in the understanding of GPCR activation combined with increasing knowledge on the diversity of signaling pathways for PTHR1 make for a fast pace in the flow of new data and new experimental approaches to study of the PTH PTHR1 system.
The discrepancy may be due to the diversity of signaling pathway(s) lying downstream of cGKII and upstream of C/EBPβ.
However, despite this diversity of signaling, MAPKs are characterized by a single pronounced specificity, namely a preference for phosphorylating proteins at a Ser/Thr-Pro motif [3].
The results presented here and previously [21] highlight the remarkable diversity of signaling mechanisms through which Aβ regulates the synaptic levels of three strongly interacting scaffold proteins in the mature PSD.
The diversity of signaling events can be mapped using proteome-wide phosphoproteomics analysis [ 18].
All of these data indicate the complexity and diversity of signaling mechanisms responsible for the transformation of MyHC isoforms in skeletal muscles under conditions of gravitational unloading.
Although MIAs promote a wide diversity of signaling events, one of the most widespread and common characteristics is the phosphorylation of anti-apoptotic Bcl-2 protein family members.
During this period, other VEGF family members were also identified, enhancing the diversity of signaling induced by the VEGF family of ligands.
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