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Studies have begun to identify both extracellular signals and signal transduction pathways that lead to the diversity of microglial behavior, although there are likely many regulators of microglial function yet to be identified.
The present study underscores the rich diversity of microglial morphologies in the hippocampus of the human brain that may change according to the diseases of aging.
Simultaneously, there might be regional diversity of microglial phenotypes, and some brain areas might be more accessible to peripheral leukocytes (de Haas et al., 2008; Scheffel et al., 2012).
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Histological examination of microglia also provides an opportunity for research because the diversity and heterogeneity of microglial morphology that can be observed in well-stained sections of human brain, particularly with Iba1 antibody, is remarkable and stands in contrast to rodents where microglial morphology is rather uniform.
Cd11b is a marker of microglial activation.
The researchers used neurochemical imaging to measure the level of microglial activity.
Extended Data Fig. 7 Analysis of microglial enhancers.
Quantitating the subtleties of microglial morphology with fractal analysis.
Supplementary Figure 11 CCL2 dependent recruitment of microglial cells.
Beutner, C. Roy, K. Linnartz, B. Napoli, I. Neumann, H. Generation of microglial cells from mouse embryonic stem cells.
Positron Emission Tomography allows for the quantification of microglial activation by labelling the Translocator Protein 18 kDa (TSPO), which becomes overexpressed upon activation of microglial cells.
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