Sentence examples for diversity of downstream from inspiring English sources
As new data emerges, it is becoming clear that the diversity of downstream functions observed result from extremely intricate and tightly regulated mechanisms that control NFκB activation in a cell-, stimulus-, and temporal-specific manner.
The influence of the wnt signalling on the target cells is modulated by a complex regulatory network integrating various inputs including the level of ligand-receptor interactions and the diversity of downstream transcriptional complexes.
High-throughput screening platforms for plasma membrane receptors have had success due to reliable cell-based systems for monitoring a diversity of downstream messengers [ 15], such as cAMP, Ca2+ mobilization, and Rho GTPase activation, or translocation of adaptor molecules after activation such as β-arrestin [ 16].
Signal transduction networks have been proposed to have conserved "bow-tie" structures in which a diversity of inputs converges on a limited number of central signalling nodes, which then fan out again to a diversity of downstream transcription factors and effector proteins [ 31].
(5) Though early studies showed the diversity of the downstream events of this ouabain-activated pathway in different cells, the postulated proximal steps seemed amenable to cell-free studies using purified Na+/K+-ATPase.
Genetic data indicate that dispersal by the Agulhas Current becomes important at a larger scale (e.g. over the entire distribution of the subtropical mudprawn lineage), as the migrants that become entrained in the Agulhas Current in the north of the species' distribution and are moved over greater distances have an impact on the genetic diversity of populations downstream [ 14].
This diversity of responses indicates that downstream events following IL-10 binding may vary depending on the cell target phenotype and on the environment of that cell, thus making the role of IL-10 in OA pathogenesis more intriguing and difficult to understand.
Tests of neutrality based on comparative genomics suggest that: (1) episodes of natural selection (likely a selective sweep) predating the coalescent of human lineages, within the last 25 million years, account for the observed reduced diversity downstream of intron 6 and, (2) the target of natural selection may not be in the SLC2A4 coding sequence.
Because of the interactions of the multi-lane freeway mainline, upstream, downstream, the diversity of environmental conditions, as well as the complexity of geometric configuration, speed-change lanes of the multi-lane freeway interchange present greatest safety and operational challenges for drivers.
The discrepancy may be due to the diversity of signaling pathway(s) lying downstream of cGKII and upstream of C/EBPβ.
In L. tigripictilis there is an intriguing general trend of lower genetic diversity at downstream sites relative to upstream sites.
